Welcome to our lab website!
The ABCD Lab is located in the center of Paris and is part of the LPS in the Physics Department of the ENS. The lab is composed mainly of physicists working in tight collaboration with biologists and chemists. Our strong experimental background has enabled the development of reliable tools to tackle diffrent lenght scales in biology: single molecule micromanipulation, single molecule fluorescence in living cells, 2-photon activation to manipulate cell fate in the zebrafish embryo, time lapse imaging of microbes.
Single molecule micromanipulations are devoted to the study of DNA and DNA-protein interactions based on a magnetic tweezers system. The lab is currently working at:
– an in-vitro reconstitution of the replication fork
– a new sequencing method of single DNA molecules
– the action of diverse helicases, topoisomerases and translocases on DNA
- At the cell level, the lab is interested in how in-vivo replication forks can restart after controlled arrest. This project involves single molecule ﬂuorescence and microﬂuidics.
- The part of the lab dedicated to developmental biology uses a 2-photon set-up to inﬂuence cell lineage in the course of embryo development by using photo-activable molecules which can be rapidly triggered in a single cell at a given time.
At the population level, the lab is focusing on bacteria growing on solid substrate:
- cooperation for iron uptake in Pseudomonas aeruginosa.
- morphogenesis of growing colonies
Postal adress: 24, rue Lhomond 75005 Paris
Phone number: +33 (0)1 44 32 34 92
Fax number: +33 (0)1 44 32 34 33