Loops in DNA: An overview of experimental and theoretical approaches

Publication Type:

Journal Article

Source:

EUROPEAN PHYSICAL JOURNAL E, SPRINGER, Volume 19, Number 3, 233 SPRING STREET, NEW YORK, NY 10013 USA, p.293-302 (2006)

DOI:

10.1140/epje/i2005-10073-y

Keywords:

COOPERATIVE BINDING; DOUBLE HELIX; LAC REPRESSOR; RING-CLOSURE PROBABILITIES; SEMIFLEXIBLE POLYMERS; SITE-SPECIFIC RECOMBINATION; STATISTICAL-MECHANICS; STRETCHING DNA; TRANSCRIPTIONAL ACTIVATION; WORMLIKE CHAINS

Abstract:

DNA loop formation plays a central role in many cellular processes. The aim of this paper is to present the state of the art and open problems regarding the experimental and theoretical approaches to DNA looping. A particular attention is devoted to the effects of the protein bridge size and of protein induced sharp DNA bending on DNA loop formation enhancement.