The manipulation of single biomolecules

Publication Type:

Journal Article

Source:

INTERDISCIPLINARY SCIENCE REVIEWS, MANEY PUBLISHING, Volume 32, Number 2, STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND, p.149-161 (2007)

DOI:

10.1179/030801807X163625

Keywords:

ATP; ELASTICITY; F-1-ATPASE; FORCE; KINESIN MOLECULES; RNA-POLYMERASE; SUPERCOILED DNA MOLECULE; TRANSLOCATION

Abstract:

By monitoring the response of individual protein and DNA molecules to pulling and twisting, biophysicists can learn much about their structure and their interactions. In this review we aim to give a flavour of the kinds of investigations that single-molecule techniques have made possible.