Oriented loading of FtsK on KOPS

Publication Type:

Journal Article

Source:

NATURE STRUCTURAL & MOLECULAR BIOLOGY, NATURE PUBLISHING GROUP, Volume 13, Number 11, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA, p.1026-1028 (2006)

DOI:

10.1038/nsmb1159

Keywords:

TRANSLOCATION

Abstract:

In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step.