Stress-induced structural transitions in DNA and proteins

Publication Type:

Journal Article

Source:

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, ANNUAL REVIEWS, Volume 29, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA, p.523-543 (2000)

Keywords:

ATOMIC-FORCE MICROSCOPY; COMPLEMENTARY STRANDS; DOUBLE-STRANDED DNA; ELASTICITY; MOLECULES; NUCLEIC-ACIDS; PICONEWTON FORCES; SINGLE; SUPERCOILED DNA; TITIN

Abstract:

The ability to manipulate, stretch and twist biomolecules opens the way to an understanding of their structural transitions. We review some of the recently discovered stress-induced structural transitions in DNA as well as the application of single molecule manipulation techniques to DNA unzipping and to the study of protein folding/unfolding transitions.