Twisting and stretching single DNA molecules

Publication Type:

Journal Article

Source:

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, Volume 74, Number 1-2, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND, p.115-140 (2000)

Keywords:

ACTIN FILAMENT; ATP HYDROLYSIS; B-DNA; DOUBLE-STRANDED DNA; ENTROPIC ELASTICITY; EXTENSION; EXTERNAL FORCE; PERSISTENCE LENGTH; RNA-POLYMERASE; SUPERCOILED DNA

Abstract:

The elastic properties of DNA are essential for its biological function. They control its bending and twisting as well as the induction of structural modifications in the molecule. These call affect its interaction with the cell machinery. The response of a single DNA molecule to a mechanical stress can be precisely determined in single-molecule experiments which give access to an accurate measurement of the elastic parameters of DNA. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.