ABCD stands for Allemand, Bensimon, Croquette and Desprat


The ABCD Lab is located in the center of Paris and is part of the LPENS in the Physics Department at ENS. The lab is composed mainly of physicists working in tight collaboration with biologists and chemists. Our strong experimental background has enabled the development of reliable tools to tackle different length scales in biology: single molecule micromanipulation, single molecule fluorescence in living cells, 2-photon activation to manipulate cell fate in the zebrafish embryo and time-lapse imaging in microbial communities.

  1. Single molecule micromanipulations are devoted to the study of DNA and DNA-protein interactions based on a magnetic tweezers system. The lab is currently working at:
        – an in-vitro reconstitution of the replication fork
        – a new sequencing method of single DNA molecules
        – the action of diverse helicases, topoisomerases and translocases on DNA
  2. The part of the lab dedicated to developmental biology uses a 2-photon set-up to influence cell lineage in the course of embryo development by using photo-activable molecules which can be rapidly triggered in a single cell at a given time.
  3. At the population level, the lab is studying the spatio-temporal organization of microbial communities:
        - morphogenesis of bacterial microcolonies on solid substrate
        - cooperative interactions
        - adhesin dynamics


Postal adress: 24, rue Lhomond 75005 Paris
Phone number: +33 (0)1 44 32 34 92
Fax number: +33 (0)1 44 32 34 33